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Challenge Dream+ Tangential Flow Filtration(TFF) System

A fully unattended tangential flow filtration system enables complete automation of the entire process, including pre-treatment, equilibration, sample loading, collection, and post-treatment. Powered by the innovative Challenge Navigator process control software from Challenge Intelligent Manufacturing, this system transforms previously intricate and time-consuming experiments into seamless and efficient operations.
01

Features

01

Simultaneously used for development and production, flexible and versatile

The system offers stable and reliable solutions for all stages, from lab-scale to pilot-scale and commercial production.

02

Convenient for linear conversion of process parameters

As a GMP-compliant system, it provides a dependable development environment with consistent process parameters, establishing a strong foundation for seamless production scale-up.

03

Smart operating system, easy to use and efficient

With a plug-and-play hardware design, the system easily transitions between various application scenarios (UF/DF/MF) and operational states (R&D/production). This design enhances efficiency and flexibility while minimizing fixed asset investment.

04

Digitization of data recording

The user-friendly Challenge Navigator software features an intuitive interface and an electronic signature system compliant with 21 CFR Part 11. It ensures process stability and repeatability while its GMP-based automation and program architecture simplify scaling processes, offering unparalleled convenience for both upscaling and downscaling.

[Applicable Products]Antibodies, vaccines, gene therapies, blood products, diagnostic reagents, antibiotics, biochemical products, traditional Chinese medicine, etc.

[Applicable Processes]Harvesting, clarification, separation and purification, concentration, dialysis, buffer exchange, microfiltration experiments.

Typical Application

Bacterial cell collection / Cell harvesting & concentration Protein concentration, purification, and buffer exchange
Plasmid purification and concentration Separation, purification, and concentration of polysaccharide molecules
Dialysis and diafiltration of latex and nanoparticles Diafiltration and concentration of liposomes
Endotoxin removal from biological samples, antibiotic raw materials, and traditional Chinese medicine Endotoxin removal from buffers and cell culture media
Removal of alcohol, concentration, and metal ion removal from blood products

Hardware & Software & Service

  • Hardware

    Integration
    Designed with a compact layout and minimal dead volume to optimize operational efficiency;
    Incorporates an integrated design for a sleek, streamlined appearance.

    Strong Compatibility
    Compatible with a wide range of filtration components, including hollow fiber membranes, flat sheet membranes, and more;
    Designed for versatility, supporting applications from lab-scale to pilot-scale, and finally to commercial production.

    Flexible and Customizable Modular Design
    Integrates fluid handling, weighing, and detection modules from leading international brands, ensuring exceptional stability and reliability;
    Online sensors for pressure, conductivity, pH, flow rate, and UV can be freely configured or combined, with space reserved for future upgrades.

    Single-Use Technology Components
    Single-Use (SU) fluid-contact components can be effortlessly replaced as needed, eliminating the need for cleaning validation, reducing cross-contamination risks, and improving process development efficiency.

  • Software

  • Service

Process Method

Method Method   Remarks
Automatic  Concentration Preset method, one-click start, let the system to calculate complex values for you
Diafiltration
Flush
Alkaline Cleaning
Filling
Water Flux 
TMP Optimization  
Manual  Self-define Process development, permission to open, making method for more flexible

Challenge Dream+ Specifications

Specification Feed pump Flow Range Environment
Challenge Dream+ 05D-SU Diaphragm pump 0-0.5L/min 0-40°C
10%-90%
Challenge Dream+ 3D-SU Diaphragm pump 0-3L/min
Challenge Dream+ 3D Diaphragm pump 0-3L/min
Challenge Dream+ 3P Peristaltic pump 0-2.3L/min